Shankar Dada MBBS is a comedy-drama film that tells the story of Shankar (played by Chiranjeevi), a kind-hearted and generous individual who donates a kidney to his friend. However, due to a mix-up, Shankar's kidney is transplanted into the body of a brain-dead patient, Raja (also played by Chiranjeevi). The movie follows Shankar's journey as he navigates through the complexities of the medical system and ultimately becomes a doctor.