Onimusha 2: Samurai's Destiny is set in feudal Japan, where players take on the role of Soki, a young samurai tasked with escorting a princess named Yuki to a safe location. However, things take a turn when Soki is ambushed by supernatural creatures, and Yuki is kidnapped by the main antagonist, Onimusha. The game features a mix of action, adventure, and puzzle-solving elements, with an emphasis on hack-and-slash combat.