The film is set in 1957, during the Cold War. Dr. Indiana Jones is forced to cooperate with the Soviet Union's agent, Irina Spalko (Cate Blanchett), who is on a quest to obtain an ancient crystal skull. The skull is believed to have the power to grant its possessor invincibility and control over the world. Indiana's journey takes him to Peru, where he encounters his son, Mutt (Shia LaBeouf), who has become involved with a group of treasure hunters. Alongside his ex-wife, Marion (Karen Allen), and Mutt, Indiana must stop the Soviets and prevent a catastrophe.