The film takes place a year after the events of the second movie. Dr. Dolittle (played by Eddie Murphy) is enjoying his life with his wife, Lily (played by Julie Andrews), and their children. However, his peaceful life is disrupted when a wealthy and eccentric client, Jasper Wyman (played by John Steed), hires him to find a rare and exotic animal. This sets off a thrilling adventure that takes Dr. Dolittle and his family on a wild ride.